In Caffeine Concerns: How Much is Too Much? Dr. Sack discusses how consuming too much caffeine can lead to caffeine dependence. Dr. Sack explains that ?there is no set amount of caffeine that will definitively cause dependence.? He also attributes chronic sleep deprivation to caffeine?s popularity. Additionally, Dr. Sack notes, ?We are a sleep-deprived nation trying to caffeinate our problem away rather than change our lifestyles.? Read the full article here.